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KMID : 1161520030070030255
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Animal Cells and Systems
2003 Volume.7 No. 3 p.255 ~ p.259
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Genotype distribution of the mutations in the coagulation factor V gene in the Korean population: Absence of its association with coronary artery disease
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Hong Seung-Ho
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Abstract
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Mutations in the factor V gene are major risk markers for venous thrombosis. Several factors for blood coagulation have been related with cardiovascular disease. I investigated genotype distribution for three mutations (G1691A, A2379G and G2391 A) of the factor V gene in the Korean population. Genotype frequencies were examined by polymerase chain reaction in 135 patients with coronary artery disease (CAD) and 116 healthy subjects. For the G1691A mutation (factor V Leiden), no mutation was detected in either group. Allele frequencies of A2379G and G2391A mutations were not significantly different between CAD patients and controls. Non?Caucasian populations have a considerably lower factor V Leiden allele frequency than Caucasian populations. Thus, it may be due to differences in the genetic background as well as environmental factors.
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KEYWORD
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Coronary artery disease, Factor V mutation, Korean population
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